Colony on the Run

Colony on the Run

Dec 10, 2026StrategyIndiePC (Microsoft Windows)

Colony on the Run — frequently asked questions

What platforms is Colony on the Run on?
Colony on the Run is available on PC (Microsoft Windows).
When did Colony on the Run release?
Colony on the Run was first released on December 10, 2026.

About Colony on the Run

Colony on the Run is a 2D roguelite action game set inside the human body. Starting as a single bacterium, players must multiply their colony, evade immune cells, and evolve new abilities to survive. Explore different organs, each featuring unique environmental hazards and challenges. Survive attacks from white blood cells and powerful bosses while preparing for a devastating antibiotic wave at the end of each stage. But survival comes with a twist: if the human host dies, it's game over for the bacteria too. Developed by a practicing respiratory physician, Colony on the Run combines fast-paced survival action with a unique microscopic setting.

Summary via IGDB.

Game details

Game modes
Single player
Themes
Action
Official site
Visit

Details via IGDB.

Every version compared

Prices, contemporary reception and the studio credited for each release

Also released on: PC (Microsoft Windows). We haven’t priced or authenticated that version yet.

Colony on the Run screenshots

Colony on the Run screenshot 1Colony on the Run screenshot 2Colony on the Run screenshot 3Colony on the Run screenshot 4Colony on the Run screenshot 5

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